Eric Topol

Eric Topol


physician-scientist, author, editor. My new book is #DeepMedicine https://t.co/qin1EM5r23

171989 followers  •  475 follow  •    •   https://t.co/fYzaAmKQ2A

2 paths of perception: bottom-up (classical) or top-down #brain  prediction via priors, Bayesian ("prediction machine model") In The Neuroscience of Reality, by @anilkseth  @sciam 

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The relationship of blood pressure and #brain  structure over human lifespan: implications for treating BP earlier (~age 40) and lack of connect w/ #Alzheimers  by et al #OA  @TheLancetNeuro  @jmschott  @JBar_UK  @ucl  @UCLIoN  @UCLBrainScience  @drcionucl 

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Interesting that the lipophilic statins (atorvastatin, lovastatin, and simvastatin) were the only ones associated with protection from liver #cancer  @AnnalsofIM 

"It is one of the latest examples of how companies across sectors are digitizing operations to increase efficiency, reduce human error and free up employees for tasks that require more human judgment" Works for @Airbus , could also do so for medicine.

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People talk about how life is like being on a treadmill. But not this kind. Designed to make you fall off! by 's Shane King, @BioMedCentralael '>Mic @BioMedCentralael @VanderbiltUGoldfarb 

Does #obesity  lead to shorter or longer life expectancy? This #dataviz  and explanation is very instructive, a perfect teaching tool. By @albertocairo , author of forthcoming book How Charts Lie, in @sciam  ($)

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In the new @sciam  exploring truth, lies and uncertainty, good to see words of wisdom from my friend John Ioannidis@METRICStanford  on #openscience  and the critical need for replication

@JAMADerm  @UniHeidelbergB  @natureTW  The skin markings and the ruler are prototypic of "label leakage " And this "Do No Harm " roadmap is #AIfree  access for 30 days, so if you d @NatureMedicineon 't have access, but have interest, suggest downloading it

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Today US Preventive Services Task Force new recommendations for #BRCA  screening in women w/multiple @JAMA_current  papers, editorials. I think this one summarizes the status best, by Rachel Yung, @laroo_wa  @JAMAOnc  Still evolving....the story in men ignored

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The #US  now spends more than $11,000 per person for healthcare, while the #UK  ~ $4,000. Yet life expectancy has declined in the for each of the past 3 years, while it continues to increase in the (graph adopted from )

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It's even worse than that. In the US, 3 consecutive years of declining life expectancy (unprecedented) and now ~$11,000 per person #healthcare  spending @ECONdailycharts  @TheEconomist 

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My favorite papers challenge biomedical dogma. Here's my summary of the ones in 2018 that provided evidentiary shakeups.

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Some features contrasting old and new medicine

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I try to keep my head down, but this crosses the line. It's time for Director to stand up to this form of censorship. Please.

For the 1st time in US history, the lines crossed in 2017. #Healthcare  became our largest source of jobs, exceeding retail. Data from

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As I approach a decade on @Twitter , some things I've learned for it's utility for science and medicine: 1. By using (exported as a PDF format), I can usually find any article I've cited, searching a word or hashtag. So tweeting became my 1° archival method

Whoa. The gut #microbiome  of elite athletes (marathon runners) has a bacterium that enhances performance, makes mice run longer, and this is mediated via lactate metabolism @NatureMedicine  (file under more amazing stuff)

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The human gut #microbiome  never ceases to amaze me. Now a discovery of a bacterium that coverts Type A or B blood to type O, with big implications for blood transfusion. by Steven Withers an @NatureMicrobiol  co @PRahfeldleagues  @UBC 

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