NEJM

NEJM


The New England Journal of Medicine (http://t.co/YKINVyRNEl) is the world’s leading medical journal and website.

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In this audio interview conducted on September 14, the editors discuss new studies that measure the effectiveness of booster doses in raising antibody levels and protecting against Covid-19.

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Incidence of blood-culture confirmed typhoid fever lower among children who received Vi-TCV vaccine than those who received control.

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Public Option 2.0 may be the most realistic way to guarantee universal coverage with a broad choice of providers and with medical prices held down by the government.

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As of July 29, 2021, a total of 2022 cases of congenital syphilis were reported to the CDC, surpassing the number of cases reported in 2019 and the highest case count since 1994.

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A 26-year-old woman with two prior cesarean deliveries presented in preterm labor. Placental vessels were visualized during surgery.

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Treatment for acute uncomplicated appendicitis may involve appendectomy or nonoperative care. Shared decision making is recommended.

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Erin Fuse Brown discusses lessons from U.S. states that have enacted public option health plans.

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DESTINY-Lung01: Trastuzumab deruxtecan showed durable anticancer activity in 91 patients with HER2-mutant NSCLC. Safety profile included interstitial lung disease that was fatal in two. #ESMO21 

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KEYNOTE-836: In advanced cervical cancer, median PFS was 10.4 months with pembrolizumab and 6 months with placebo. Overall survival at 2 years was 50.4% and 40.4%, respectively. #ESMO21 

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Quick Take: Salt Substitute and Cardiovascular Events

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Why has the United States handled this pandemic so badly? The Editors note that although we came into this crisis with enormous advantages, our current political leaders have demonstrated that they are dangerously incompetent.

“Two semi-trailer trucks, cleverly marked as food-service vehicles, met us at the warehouse. When fully loaded, the trucks would take two distinct routes back to Massachusetts to minimize the chances that their contents would be detained or redirected.” #COVID19 

If medical students and trainees are taught to recognize symptoms of disease in only white patients and learn to perform lifesaving maneuvers on only male-bodied mannequins, medical educators may be unwittingly contributing to health disparities.

Medical students have higher rates of depression, suicidal ideation, and burnout than the general population. Schools have begun revisiting their procedures to ensure that they are doing everything possible to meet the #mentalhealth  care needs of their students.

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy.

Just published: article from China CDC describes a novel coronavirus detected in patients with pneumonia whose specimens were tested at an early stage of the outbreak. The authors describe clinical features of the pneumonia in three of these patients.

Two inoculations with a new SARS-CoV-2 mRNA-based vaccine that encodes a protein in the coronavirus spike elicited high titers of virus-neutralizing antibody in healthy adult volunteers. Virus-specific T-cell responses were also elicited. #COVID19  #SARSCoV2 

A 36-year-old man was admitted to the ICU with an acute exacerbation of chronic #heartfailure . After a ventricular assist device was placed & anticoagulation therapy initiated, hemoptysis developed, and he expectorated a cast of the right bronchial tree.

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In a study involving 10.2 million participants in Chile, the effectiveness of an inactivated, China-developed#SARSCoV2  vaccine was estimated. Effectiveness was 65.9% for infection, 87.5% for hospitalization, 90.3% for ICU admission, and 86.3% for death.

Data on 8910 patients hospitalized with a diagnosis of #COVID19  were analyzed. Neither the use of angiotensin-converting–enzyme inhibitors nor the use of angiotensin-receptor blockers was associated with an increased risk of in-hospital death.

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