NEJM

NEJM


The New England Journal of Medicine (http://t.co/YKINVyRNEl) is the world’s leading medical journal and website.

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AK002, an anti–Siglec-8 antibody, reduced eosinophils and symptoms of gastritis and duodenitis with frequencies of adverse events similar to placebo, although infusion-related reactions were more common with AK002.

Join clinical experts, thought leaders, and advocates for a collaborative discussion on the issues of health disparities, structural racism, and medicine as we examine specific dermatologic diseases. Register for 1 or all 4! @SkinOfColor  @VisualDx  #skinofcolor  #dermtwitter 

Sensory ganglionopathy is characterized by sensory loss without weakness. A common pathophysiological mechanism is autoimmunity. This review focuses on acquired sensory ganglionopathies, most commonly seen in patients with an autoimmune disease or a paraneoplastic disorder.

The NEJM Race and Medicine topic page features a selection of NEJM articles on race and medicine with implications for improving patient care, professional training, research, and public health. All articles assembled on the page are freely available.

A 52-year-old woman presented with painless, bilateral parotid swelling. Imaging showed dilatation of the parotid (Stensen’s) ducts, and palpation resulted in profuse bilateral salivary discharge. A video shows saliva firing from the parotid ducts.

A 55-year-old-man with a history of neurofibromatosis and chronic necrotizing pancreatitis presented with abdominal pain and recurrent painful skin lesions. Read the full MGH case record.

In patients with chronic kidney disease and type 2 diabetes, treatment with finerenone resulted in lower risks of CKD progression and cardiovascular events than placebo. #KidneyWk 

This interactive feature about a man hospitalized with Covid-19 whose condition is worsening offers a case vignette accompanied by two essays, each of which recommends a different approach to anticoagulation for the prevention of VTE in a patient with severe Covid-19.

A recent study showed that the differentiation of fibroblasts in the sublining of the synovium of the rheumatoid joint capsule is influenced by the vascular endothelium and implicates the Notch3 receptor in this process.

Among women in low-resource countries who were at risk for early preterm birth, the use of antenatal dexamethasone resulted in lower risks of neonatal death alone and stillbirth or neonatal death than the use of placebo.

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Why has the United States handled this pandemic so badly? The Editors note that although we came into this crisis with enormous advantages, our current political leaders have demonstrated that they are dangerously incompetent.

“Two semi-trailer trucks, cleverly marked as food-service vehicles, met us at the warehouse. When fully loaded, the trucks would take two distinct routes back to Massachusetts to minimize the chances that their contents would be detained or redirected.” #COVID19 

If medical students and trainees are taught to recognize symptoms of disease in only white patients and learn to perform lifesaving maneuvers on only male-bodied mannequins, medical educators may be unwittingly contributing to health disparities.

Medical students have higher rates of depression, suicidal ideation, and burnout than the general population. Schools have begun revisiting their procedures to ensure that they are doing everything possible to meet the #mentalhealth  care needs of their students.

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy.

Two inoculations with a new SARS-CoV-2 mRNA-based vaccine that encodes a protein in the coronavirus spike elicited high titers of virus-neutralizing antibody in healthy adult volunteers. Virus-specific T-cell responses were also elicited. #COVID19  #SARSCoV2 

Dying in a Leadership Vacuum #COVID19 

Just published: article from China CDC describes a novel coronavirus detected in patients with pneumonia whose specimens were tested at an early stage of the outbreak. The authors describe clinical features of the pneumonia in three of these patients.

Data on 8910 patients hospitalized with a diagnosis of #COVID19  were analyzed. Neither the use of angiotensin-converting–enzyme inhibitors nor the use of angiotensin-receptor blockers was associated with an increased risk of in-hospital death.

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